Hydrotropic solubilization: a green review on - analytical approach for hydrotropic solubilization technique via spectrophotometric estimation of API

Doi: https://doi.org/10.55522/ijti.v4i5.0162

Abstract

The pharmaceutical industry is increasingly focused on developing environmentally sustainable analytical methods that minimise the use of hazardous chemicals while maintaining analytical reliability. Poor aqueous solubility of many active pharmaceutical ingredients (APIs), including Esomeprazole and Levosulpiride, presents significant challenges during analytical method development. Conventional analytical methods frequently require toxic organic solvents such as methanol and acetonitrile, leading to environmental and occupational concerns. Hydrotropic solubilization has emerged as an effective and eco-friendly alternative for enhancing the aqueous solubility of poorly water-soluble drugs. This review discusses the concept, mechanism, classification, and applications of hydrotropic agents in pharmaceutical analysis. Special emphasis is placed on the analytical challenges associated with Esomeprazole and Levosulpiride and the potential application of hydrotropic solubilization for their spectrophotometric estimation. The review highlights recent developments in green analytical chemistry and demonstrates how hydrotropic techniques contribute to sustainable pharmaceutical quality control practices.