A Review of Bacillus Species Alkaline Protease Production and Industrial Applications

Shilpa Gautam*, Deepak Mishra

AKS University, Satna, Madhya Pradesh, India

Refer this article

Shilpa Gautam, Deepak Mishra. A Review of Bacillus Species Alkaline Protease Production and Industrial Applications. November-December 2024, V2 – I6, Pages - 0266 – 0273. Doi: https://doi.org/10.55522/ijti.v2i6.0091.

ABSTRACT

Protein peptide linkages can be hydrolyzed by protease enzymes. They are present in every living thing. Because they are essential to many biological processes and the life cycle of many diseases, bacterial proteases are important medicinal ingredients. Enzyme delivery methods and new technology for rationally engineering proteases will considerably enhance the potential therapeutic applications of enzymes. Proteases are widely used agents in several pharmaceutical business industries. Proteases are present in every living thing. Because of their role in the life cycle of different pathogenic organisms, they could be targeted for the development of therapeutic drugs to treat serious illnesses such as AIDS, cancer, malaria, and bacterial infections. The uses of microbial proteases, including xiaflex, L-asparaginase, L-glutaminase, serrapeptase, serrazime, and L-asparaginase, are the primary emphasis of this review. These enzymes are being utilized to treat cancer, respiratory illnesses, cardiovascular disease, and inflammation. In microbial fermentations, Bacillus species remain the predominant bacterial workhorses. The primary microorganism involved in fermentation is Bacillus subtilis, or natto. Certain Bacillus species are included in the Food and Drug Administration's GRAS (generally regarded as safe) list. Some of the most significant commercial enzyme manufacturers are Bacillus strains that can synthesize and secrete high amounts of extracellular enzymes (20–25 g/L). To summarize the medicinal uses of Basillus protease enzymes in the biological sciences, this paper will discuss the biotechnological features of these enzymes.

Keywords:

Bacterial proteases, pharmaceutical applications, pathogenic, Protease.